The Effect of Familial Burden and Environment on the Progress of Allergic Diseases in the last 10 years in the Czech Republic

Lucie Pagáčová The effect of familial burden and environment on the progress of allergic diseases in the last 10 years in the Czech Republic Rigorous thesis Charles University in Prague, Faculty of Pharmacy in Hradec Kralove INTRODUCTION: This wide-range study consists of three researches based on questionnares which were done in the years 2002, 2005 and 2011. They are based on questions regarding alergies in families, alergies which our proband has or does not have, questions about the period of pregnancy, delivery, early childhood etc. Results from each study were compared with the other studies we made, including studies made abroad. Areas which we focused on were the enviroment in which the proband lives, which type of dwelling it resides in or did reside in, familial burden, if have allergic family members an influence to develop an allergy and we bring new dates about allergic situation in the Czech Republic. We ultimately evaluate the effect of sex and date of birth. OBJECTIVES: We tried to point out the heredity of allergic disease, bringing new results and individually comparing them with our three studies. We presented you with the name ‚epigenetics' and we pointed out the possible influences responsible for allergic expression. We compared our results with situations abroad. METHODS:..