Influence of Polyphenolic Substances with Iron Chelating Activity in Model of Acute Myocardial Infarction and Oxidation Stress Induced by Catecholamines

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate Mgr. Libuše Zatloukalová Supervisor Prof. MUDr. Radomír Hrdina, CSc. Title of Doctoral Thesis Influence of polyphenolic substances with iron chelating activity in model of acute myocardial infarction and oxidation stress induced by catecholamines Background and aim: Ischaemic heart disease (IHD) and particularly its most serious form - acute myocardial infarction (AMI) - represents significant health problem in the developed countries with relatively high mortality. Within multifactorial pathogenesis of AMI, reactive oxygen and nitrogen species (RONS) generated by free iron catalytic effect and increased activity of the sympathetic nervous system accompanied with a release of the catecholamines play a significant role. Large doses of the synthetic katecholamine isoprenaline has been used as a suitable experimental model of AMI. AIM is considered as typical form of ischaemic-reperfusion (I-R) injury. RONS, which are excessively released during the first minutes of reperfusion, play a significant role in the pathogenesis of myocardial I-R injury. Free iron significantly increases the process of RONS generation. Use of iron chelators could have protective influence in I-R injury and..