The study of directly compressible tableting materials with agglomerated α - lactose monohydrate and lubricants

Charles University, Faculty of Pharmacy in Hradec Králové Department Pharmaceutical Technology Candidate Mgr. Barbora Vyhlídalová Consultant PharmDr. Jitka Mužíková, Ph.D. Title of the Thesis The study of directly compressible tableting materials with agglomerated α - lactose monohydrate and lubricants This work deals with the study of tabletting materials, which contain agglomerated α- lactose monohydrate (Tablettosa® 80) and four types of lubricants at concentration of 1%. The used lubricants were magnesium stearate, calcium stearate, sodium-stearyl-fumarate and glyceryl behenate. Flow properties of the mixtures, energy profile of the compression process, ejection force, tensile strength and disintegration time of tablets were evaluated. The compression parameters and the properties of tablets were evaluated depending on the compressiion force. The flow properties were most improved by magnesium stearate. Glyceryl behenate didn't affect them. Total energy of the compression process increased with increasing compression force. The mixture with calcium stearate had the lowest value of total energy and the mixture with sodium-stearyl-fumarate had the highest value. Plasticity decreased with increasing compression force. Values of the ejection force showed that glyceryl behenate can't be used at..