The effect of quercetin and its selected metabolites on isolated aortal rings of rat

v anglickém jazyce Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Candidate: Mgr. Kateřina Šumpelová Supervisor: PharmDr. Marie Vopršalová, CSc. Title of rigorous thesis: The effect of quercetin and its selected metabolites on isolated aortal rings of rat Quercetin and it's metabolites are classified into the group of flavonoids. Flavonoid compounds are substances widely extended in nature. They below to the secondary metabolites of plants and have positive effect on live organism. Individual effects of flavonoids on the organism were described in this thesis, especially the effects on cardiovascular system. Flavonoids can have vasodilatory activity, antioxidant or anti-inflammatory effect. The experimental parts of the thesis dealing with the effect of quercetin and it's metabolites tamarixetin and isorhamnetin on isolated aortal rings of rat in vitro. Significant vasodilatory activity of these flavonoids was observed. The mechanism of the vasodilatory effect of qeurcetin was verified. Our experiments confirm the theory that the effect is independent on the function of endotel