The impact of metabolic parameters on cognitive functions in bipolar patients treated with mood stabilizers

TITLE: The impact of metabolic parameters on cognitive functions in bipolar patients treated with mood stabilizers. OBJECTIVE: Cognitive impairment in euthymic phase of bipolar disorder has been documented in many studies. There are several contributing factors exerting detrimental effect to such an impairment, e.g. sedative medication, thyreopathy. Cardiometabolic rick factors constitute another frequent condition found in bipolar disorder and exerting probably adverse impact on cognition. Since this condition is treatable and current literature suggests possible connection with cognitive dysfunction, this study aimed to explore such associations to identify promising targets of complex treatment. METHODS: Forty euthymic bipolar patients were enrolled into a prospective one-year study. Patients underwent the examination in the beginning of the study and one year after. Their body and metabolic parameters were measured. Medical history data were collected. Cognition was evaluated using battery of tests. Neuropsychological performance was transformed into neurocognitive composite score. Cognition of subjects was compared dichotomously according to presence or absence of pathological body and metabolic parameters. Correlations of selected parameters and composite score were done. RESULTS: Low..