Use of DSC to Determinate Volume of Active Substances II

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Pharmaceutical Technology Candidate Mgr. Eva Víchová Consultant RNDr. Marie Musilová, CSc. Title of Thesis Use of DSC to determinate volume of active substances ll This thesis deals with the determination of paracetamol in commercially produced Panadol Baby suppositories. Differential scanning calorimetry was used for this evaluation. This method detects the amount of heat needed to melt paracetamol. The heat quantity is directly proportional to the amount of the drug in the sample. The content is then calculated from the equation of the calibration curve. The thesis includes the measurement record of total twenty samples and the samples deals with the calibration curve. There was found higher content of paracetamol in the tips than in the circular bases. For all samples there was found lower content of drug than was declared. We recommend to compare the results obtained by DSC with another analytical method