Osmolality of parenteral preparations. Parenteral mixtures 1.

Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Veronika Bouallagui Title of Thesis: Osmolality of parenteral preparations. Parenteral mixtures 1. In this work, density and osmolality of isotonic solutions of sodium chloride and glucose and their mixtures was measured in the molal and / or molar concentration, respectively. Osmolality was directly proportional to the increasing concentration of substance, but this is true only for solutions themselves substances; osmolality was affected by the ratio of sodium chloride and glucose in mixtures. The density of the solutions was measured at 20řC and 25řC, the average density at 20řC was used for the conversion of molality to molarity and vice versa, to estimate the osmolarity and to estimate the partial specific volume Vg (ml/g) and molal volume Vmol (ml/mol) of the solute. Partial specific volume and molal volume of glucose not relate directly to concentration of substance while decreased for sodium chloride with decreasing concentration of substance. Resulting value Vg and Vmol for mixtures of both compounds were affected by the concentration and the ratio of the two components in the mixture. Out of the three methods..