Calcitonin gene related peptide induced changes of internal homeostatic body model; translation from TCD studies

Intravenously introduced Calcitonin gene-related peptide (αCGRP) induces CGRP- induced headache (CGRP-IH) as well cerebral and systemic hemodynamic changes detectable with transcranial Dop- pler sonography (TCD). Therefore, elevation of CGRP in the systemic blood can evoked headache in predisposed subjects, especially in migrainours. Thus, increase of CGRP during migraine episode might be source of nociceptive sensation. Following predictive coding and interoception, this could induce painful prediction error and updates the internal homeostatic model, inducing headache, and turn subject into no fit to purpose mode which leads to disability during migraine episode. The CGRP provocation might be used for discrimination of CGRP sensitive from insensitive migraine using TCD and predict CGRP antagonism effect in migraine treatment