International audiencePressure-induced vasodilation (PIV) delays the decrease in cutaneous blood flow produced by local application of low pressure to the skin, a physiologically appropriate adjustment of local vasomotor function. Individuals without a normal PIV response have a high risk of ulceration. Here we demonstrate that acid-sensing ion channel 3 (Asic3) is an essential neuronal sensor for the vasodilation response to direct pressure in both humans and rodents and for protecting against pressure ulcers in mice
Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all ev...
AbstractGastric acid is of paramount importance for digestion and protection from pathogens but, at ...
Published in Journal of Comparative Neurology, 2007; 500 (5):863-875 at www.interscience.wiley.comRe...
Ischemic pain occurs when there is insufficient blood flow for the metabolic needs of an organ. The ...
AimsMembers of the acid sensing ion channel (ASIC) family are strong candidates as mechanical transd...
Acid-Sensing Ion channel 3 (ASIC3) is a member of the ASIC family (ASIC1-4), which are excitatory io...
Abstract Background Inflammation-mediated hyperalgesia involves tissue acidosis and sensitization of...
International audienceIn rodent sensory neurons, acid-sensing ion channel 3 (ASIC3) has recently eme...
In our lab, two neurovascular mechanisms required for functional integrity of the skin are studied. ...
The reflex that provides rapid neural control of blood pressure is triggered by an unknown molecular...
Background: Inflammation-mediated hyperalgesia involves tissue acidosis and sensitization of nocicep...
Abstract Background Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gate...
Background & Aims: Visceral mechanoreceptors are critical for perceived sensations and autonomic ref...
Gastric acid challenge of the rat and mouse stomach is signalled to the brainstem as revealed by exp...
International audienceTissue acidosis is an important feature of inflammation. It is a direct cause ...
Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all ev...
AbstractGastric acid is of paramount importance for digestion and protection from pathogens but, at ...
Published in Journal of Comparative Neurology, 2007; 500 (5):863-875 at www.interscience.wiley.comRe...
Ischemic pain occurs when there is insufficient blood flow for the metabolic needs of an organ. The ...
AimsMembers of the acid sensing ion channel (ASIC) family are strong candidates as mechanical transd...
Acid-Sensing Ion channel 3 (ASIC3) is a member of the ASIC family (ASIC1-4), which are excitatory io...
Abstract Background Inflammation-mediated hyperalgesia involves tissue acidosis and sensitization of...
International audienceIn rodent sensory neurons, acid-sensing ion channel 3 (ASIC3) has recently eme...
In our lab, two neurovascular mechanisms required for functional integrity of the skin are studied. ...
The reflex that provides rapid neural control of blood pressure is triggered by an unknown molecular...
Background: Inflammation-mediated hyperalgesia involves tissue acidosis and sensitization of nocicep...
Abstract Background Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gate...
Background & Aims: Visceral mechanoreceptors are critical for perceived sensations and autonomic ref...
Gastric acid challenge of the rat and mouse stomach is signalled to the brainstem as revealed by exp...
International audienceTissue acidosis is an important feature of inflammation. It is a direct cause ...
Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all ev...
AbstractGastric acid is of paramount importance for digestion and protection from pathogens but, at ...
Published in Journal of Comparative Neurology, 2007; 500 (5):863-875 at www.interscience.wiley.comRe...