Effects of the Mycotoxin Penicillic Acid on Electrogenic Sodium Transport and Associated Adenosine Triphosphatase

Program year: 1981/1982Digitized from print original stored in HDRThe effects of the mycotoxin penicillic acid on short circuited intact toad bladder and on Na⁺-K⁺, activated ATPase were examined to determine the relationship between toxin, the Na⁺-K⁺ ATPase enzyme system and associated active sodium transport. Penicillic acid inhibited transbladder short circuit current and Na⁺-K⁺ ATPase from isolated bladder preparations. The effect was time and dose dependent. The results are compatible with the assumption that Na⁺-K⁺ ATPase is associated with the pump mechanism since penicillic acid inhibited enzyme activity and reduced the rate of electrogenic Na⁺ transport