Surgical evaluation in children <3Â years of age with drug- resistant epilepsy: Patient characteristics, diagnostic utilization, and potential for treatment delays
- Perry, Michael Scott
- Shandley, Sabrina
- Perelman, Max
- Singh, Rani K.
- Wong-Kisiel, Lily
- Sullivan, Joseph
- Gonzalez-Giraldo, Ernesto
- Romanowski, Erin Fedak
- McNamara, Nancy A.
- Marashly, Ahmad
- Ostendorf, Adam P.
- Alexander, Allyson
- Eschbach, Krista
- Bolton, Jeffrey
- Wolf, Steven
- McGoldrick, Patricia
- Depositario-Cabacar, Dewi F.
- Ciliberto, Michael A.
- Gedela, Satyanarayana
- Sannagowdara, Kumar
- Karia, Samir
- Shrey, Daniel W.
- Tatachar, Priya
- Nangia, Srishti
- Grinspan, Zachary
- Reddy, Shilpa B.
- Shital, Patel
- Coryell, Jason
DOIAbstract
ObjectiveDrug- resistant epilepsy (DRE) occurs at higher rates in children 1 year) after DRE diagnosis in the very young.ResultsThe cohort included 437 children, of whom 71 (16%) were <3 years of age at referral. Children evaluated before the age of 3 years more commonly had abnormal neurological examinations (p = .002) and daily seizures (p = .001). At least one ancillary test was used in 44% of evaluations. Fifty- nine percent were seizure- free following surgery (n = 34), with 35% undergoing limited focal resections. Children with delayed referrals more often had focal aware (p < .001) seizures and recommendation for palliative surgeries (p < .001).SignificanceThere are relatively few studies of epilepsy surgery in the ver...
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