Evaluate the biomarkers of bone turnover in patients with in sickle cell anemia in Basra province

Background: Sickle cell anemia (SCD) is one of many haemoglobinopathic disorders which is probably the most common known hereditary blood disorder. In this disease, the homozygous state in which the sickle gene is inherited from the father and the mother, and patients with sickle cell disorders often suffer from chronic hemolytic anemia, which causes bone marrow hyperplasia too.  The present study was designed to evaluate the biomarkers which related with the bone turnover in sickle cell anemia  patients. Patients with SCA (n=120) 60 males and 60 females were on follow up in the Basra center for Hereditary Blood Disease, who were included in this study and age and sex matched healthy persons (n=60) as controls. biomarkers had important role in many biological processes. Aims: of this study to measure serum levels of different biomarkers such as; BCTx, BSAP, CRP, DPD, IGF-1, OT, TRACP-5b, FER, IGFBPT, Intact (iPTH), Ostase, PINP and serum Ca+. Using Kruskal-Wallis test as statistical test, markers in sickle cell anemia and control groups.The results: showed no significant difference of both male and female patients (HbSS, HbSC and sickle- β-Thalassemia) in compared to control group.&nbsp