Polymorphism in the Toll-Like Receptor 2 gene in patients with urinary tract infections

Urinary tract infection (UTIs) are considered to be the most common infections in human The  present  study  aimed  to  investigate  the  association  between  single  nucleotide polymorphisms (SNPs) in the toll-like receptor 2 (TLR2) gene and the incidence of Urinary Tract InfectionA  total  of  100  urine specimens and and venous blood sample from patients and (50) control collected from patients who are suffering from urinary tract infection who attended to Al-Imam Al-Sadiq Hospital/ Babylon,  and Al-Hilla General Teaching Hospitalduring the period from February to October 2020The aim of the present study was to determine ΤLR2 expression during the UTI  infection  by measuring the TLR2 in serum and urine  We also attempted to compare the TLRs expression with the immunological status of the patients to healthy The concentration level of the TLR-2 (systemic and mucosal) was determined by Enzyme Linked Immunosorbent Assay (ELISA)method. The concentration level of TLR-2 mucosal molecule with mean value (3.877) pg./ml respectively while the control group with mean value (3.318) pg. /ml , The concentration level of TLR-2 systemic molecule with mean value (5.023)pg./ml respectively while the control group with mean value (2.759)pg./ml