Immunological, bacteriological and genetic factors may modulate the risk of gallbladder disease among Iraqi patients

Background:. Gallstone disease(GSD) is a prevalent illness worldwide. Patients  and  methods: During a duration of 3 months October/2020 to December /2021, samples were collected from160 patients diagnosed with gallstone disease by Ultrasound method, and 60 healthy individuals, who were attended Safer Al-Hussein Surgical Hospital /Karbala and Imam Al-Hussein Medical –City /Karbala. The specimens were collected from bile and an inner surface of the gallbladder with aseptically. The specimens were treated immediately after they reach to the laboratory following the standard laboratory procedures. The patient were examined by the surgery specialist. Results: resulting data shows a considerable variance (P < 0.05) between the condensation for IL_1 α in the blood of patients and healthy people, and there is a non-considerable difference (P > 0.05) in the concentration from VP in sera of subjects tested. Conclusion: elevation in IL-1α-level and a non-considerable difference in VP condensation