In vivo antipyretic activity of Scutia myrtina acute oral toxicity study

Pyrexia or Fever is defined as an elevation of body temperature. It is a response due to tissue damage, inflammation, malignancy or graft rejection. Cytokines, interleukin, interferon and Tumor Necrosis Factor α (TNF- α) are formed in large amount under this condition, which increase PGE2 which in turn triggers hypothalamus to elevate body temperature. The present investigation it may be concluded that the hydroalcoholic extract of leaves of Scutia myrtina has antipyretic activity.it is tested by in vivo method by using rat .In this study the hydroalcoholic extract contain fever reducing activity