To compare the hemodynamic changes produced by the drug after the usage of Midazolam as an adjunct to bupivacaine in brachial plexus block

Introduction: Bupivacaine, a local anesthetic, in brachial plexus block produces highly efficient intraoperative anesthesia and also analgesia. This study was carried out to observe the effect of the addition of midazolam to local anesthetic in brachial plexus block in the intraoperative and post-operative period. Objective: To compare intraoperative and post-operative Hemodynamic changes (pulse rate, systolic blood pressure, diastolic blood pressure, respiratory rate) with bupivacaine alone and bupivacaine-midazolam combination. Methodology: A randomized clinical trial was conducted on 70 ASA-I or II adult patients undergoing upper limb surgeries (scheduled for forearm and hand surgery) under axillary brachial plexus block. Patients were randomly allocated into two groups of 35 each. Patients in group A were administered 30 ml of 0.5% bupivacaine and those in group B were given 30 ml of 0.5% bupivacaine with midazolam 50 µg·kg–1. Results: The mean (±SD) age of patients in Group A and B were 37.97± 13.73 years and 39.28± 14.19 years respectively. Hemodynamic variables (pulse rate, systolic blood pressure, diastolic blood pressure, respiratory rate) were recorded and compared using the student’s test (paired for intragroup and unpaired for intergroup comparison) and Chi-Square test. P-value <0.05 was taken to be statistically significant and <0.001 highly significant