FG comparative study between antigen-antibody complex vaccine and traditional vaccine of infectious bursal disease in commercial broiler

Infectious bursal disease (IBD) is a viral disease causes increased mortality and severe immunosuppressionin commercial chickens. The virus infects the bursa of Fabricius of particularly the actively dividing and differentiating lymphocytes of the B-cellslineage of young chickens, resultant in morbidity, mortality, and immunosuppression. Immunosuppression enhances the susceptibility of chickens to other infections and interferes with vaccination against other diseases. Immunization is the most important measure to control IBD; however, wild usage of live vaccines has resulted in the evolution of new strains. Although the immunosuppression caused by IBDV is more directed toward the B lymphocytes, the protective immunity in birds depends on inducement of both humeral and cell-mediated immune responses. Currently vaccination mainly used to control IBD. In this study, Group 1(n = 50) received the immune complex vaccine (Bursa-Plex®) s/c at 1 day of age. Group 2 (n = 50) received the GUMBORO (D78)(intervet)vaccine by drinking water and Group 3 (n = 50) were non IBD vaccinated birds. The aim of study: Evaluation between two types of IBD vaccines, immune-complex IBD vaccine (Bursaplex®) with the use of GUMBORO D78(intervet) vaccine. Depending on:At 7,14,21, 28th day P.V. • Serology (IBD ELISA (INFY)- cellular immunity)