Synthesis and evaluating antimicrobial activity for chalcones thiophen compounds

This research included the preparation and characterization of compounds containing chalcones, Schiff bases, and Azo dye: bearing thiophene ring. The compounds (1mk-3mk) had prepared from the reaction acetophenone derivatives with 2-formyl thiophene and, then 2mmk had introduced in two reactions: first, its reaction with some substitutes of benzaldehyde to prepare Schiff bases (4mk-7mk), and the second was the design of a bis azo dye from p-Phenylenediamine with salicylaldehyde to get 8mk, and then reacted with chalcone 2mk to obtain the compound 9mk. The chemical formulas of the prepared compounds were confirmed by spectroscopic methods using UV, infrared, NMR spectroscopy of protons and carbon 13. The antimicrobial activity had tested against Staphylococcus aureus and Candida albicans in compared with neomycin sulfate and nystatin, and some compounds showed good to moderate inhibition at a concentration of 7.5,10 mg/ml