Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY.
- OpenSAFELY Collaborative
- Green, Amelia
- Curtis, Helen
- Hulme, William
- Williamson, Elizabeth
- McDonald, Helen
- Bhaskaran, Krishnan
- Rentsch, Christopher
- Schultze, Anna
- MacKenna, Brian
- Mahalingasivam, Viyaasan
- Tomlinson, Laurie
- Walker, Alex
- Fisher, Louis
- Massey, Jon
- Andrews, Colm
- Hopcroft, Lisa
- Morton, Caroline
- Croker, Richard
- Morley, Jessica
- Mehrkar, Amir
- Bacon, Seb
- Evans, David
- Inglesby, Peter
- Hickman, George
- Ward, Tom
- Davy, Simon
- Mathur, Rohini
- Tazare, John
- Eggo, Rosalind
- Wing, Kevin
- Wong, Angel
- Forbes, Harriet
- Bates, Chris
- Cockburn, Jonathan
- Parry, John
- Hester, Frank
- Harper, Sam
- Douglas, Ian
- Evans, Stephen
- Smeeth, Liam
- Goldacre, Ben
DOIAbstract
BACKGROUND: While the vaccines against COVID-19 are highly effective, COVID-19 vaccine breakthrough is possible despite being fully vaccinated. With SARS-CoV-2 variants still circulating, describing the characteristics of individuals who have experienced COVID-19 vaccine breakthroughs could be hugely important in helping to determine who may be at greatest risk. METHODS: With the approval of NHS England, we conducted a retrospective cohort study using routine clinical data from the OpenSAFELY-TPP database of fully vaccinated individuals, linked to secondary care and death registry data and described the characteristics of those experiencing COVID-19 vaccine breakthroughs. RESULTS: As of 1st November 2021, a total of 15,501,550 individuals w...
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