International audienceIn our work, a decision support tool has been proposed for the home-based chemotherapy management in which the patient treatment process is spread over three consecutive days. Our approach is composed of a complete patient treatment process modeling, together with a set of simulation scenarios in order to perform suitability test of the theoretical treatment process model. The discrete-event simulation model takes into account not only the resources mobilization and their availability scheduling, but also the uncertainty of accomplishment dates for some activities and decisions fulfilled by non-staff participants (i.e. Biological laboratory, family doctor, ICL pharmacy...). The performance indicators measure, on the on...