Interpreting results of contemporary neuroscientif studies, I present a non-reductive physicalist account of mind-brain relationship from which the criticism of unintelligibility ascribed to the notion of mental causation is considered. Assuming that a paradigmatic criticism addressed to the notion of mental causation is that presented by Jaegwon Kim’s analysis on the theory of mind-body supervenience, I present his argument arguing that it encompasses a formulation of the problem of mental causation, which leads to difficulties by him pointed. To ask “how mental events, being a nonphysical property of the brain, could act causally on brain structure and functioning?”, is not to treat the mind as a property of the brain, but as a Cartesian ...