Study of Serum total protein, albumin and globulin Level in Children with Malarial Infection in Civil Hospital, Ahmedabad

Introduction: Malaria is a major protozoal disease in many developing countries that is main cause of for 20-30 lakhs deaths per year. This study will give us a proper view for monitoring and management of these patients. Material and Method: Fifty children with Malaria are included in the study as cases and equal number of age and sex matched healthy children formed the control group. Study is conducted during the period of August 2014 to October 2016. Result: there is significant difference in serum Total protein levels in cases and controls (p value is 0.0393). And in serum albumin levels in cases and controls (p value is less than 0.0001) and in serum globulin levels in cases and controls (p value is 0.0114). Conclusion: Children having malaria has low serum total protein, albumin and globulin as compare to healthy individuals. Impairment of hepatic function associated with severe malaria may be responsible for the hypoproteinemia and hypoalbuminemia reported in this study. Moreover, plasma albumin is a negative acute phase protein, the level of which falls as a result of malaria infection probably due to an increase in its trans-capillary escape rat