A Study On Correlation of Various Prostate Pathology With Serum Prostate Specific Antigen at a Tertiary Care Centre in Bihar

Introduction: Diseases primarily inflicting prostate gland are inflammation, benign nodular enlargement, and tumors. Serum prostate-specific antigen (PSA), a marker for prostatic carcinoma has high sensitivity, specificity, and compliments histopathological diagnosis. Gleason's microscopic grading is a paramount feature and with PSA are important for diagnosis, management, and prognosis of carcinoma. Methodology: Clinicopathological study of 100 prostatic biopsies was conducted in the Department of General Surgery, Darbhanga Medical college and Hospital, Darbhanga, Bihar, India, over a period of One year from January 2020 to Dcember 2020. The study was approved by the Institutional Ethical Committee and all patients gave informed written consent. All patients presenting with LUTS underwent DRE and were worked up with USG KUBP, Serum PSA and biopsy (if indicated) after obtaining consent. Results: A total of 100 patients were included in the study. The mean age in our study was 62.5 years [range 50-90 years]. The majority of the patients in the study group were in the age group of 61-70 years. PSA levels of the patients were compared according to their age. The mean serum PSA for age group 50-60 years was 3.9 ng/ml, for age group 61-70 was 15.2 ng/ml, for age group 71-80 was 11.3ng/ml, for age group 81-90 was 11.4 ng/ml. The mean serum PSA for the whole group was 13.2 ng/ml. The mean serum PSA level was found to increase with each decade, starting from 50 years up to 90 years (p< 0.05). Conclusion: Mean serum PSA levels rises with increasing age. Serum PSA levels has a significant correlation with International prostate symptom severity scoring wherein mean serum PSA level rises with severity of LUTS. However, serum PSA levels do not show significant correlation with Gleason score or clinical stage of prostate cancer