Nootropic Activity of Rhodiola rosea Root

Nootropic are mediator that enhance the cognitive skills of brain function, Alzheimer’s disease, primarily affects the elderly population and is estimated to account for 50–60% of dementia cases in persons over 65 years of age. The present study aimed to evaluate the Nootropic activity of Rhodiola rosea. Methanoilc extract of R. rosea was used to estimate elevated plus maze (EPM) model in mice, the effect of extract on learning and memory in number of entries open and closed arms using the EPM in mice at a dose of 300 and 500 mg/kg. R. rosea extract in EPM showed transfer latency entries, which is indicative of cognition improvement. The results suggested that the treatment of methanolic extract of R. rosea enhances memory in EPM experimental models