Add to ORKGA mutation within the alpha-synuclein gene on human chromosome 4 has been reported to segregate with PD in an Italian family. We screened a sample of familial cases of PD for mutation in the alpha-synuclein gene. None of the familial cases of PD carried a mutation within the alpha-synuclein gene, and no association was detected between PD and alleles of a dinucleotide repeat marker within the alpha-synuclein gene. We conclude that variation within the alpha-synuclein gene does not play a significant role in the risk for PD in our sample
In the past few years, the genetic contribution to Parkinson's disease (PD) has gained major attenti...
Introduction: Missense variants and multiplications of the alpha-synuclein gene (SNCA) are establish...
Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder. Aging, environmental fac...
Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence of approxi...
In a previous study, we detected an association between a dinucleotide repeat (Rep1) in the alpha-Sy...
Parkinson's disease (PD) is a common progressive neu-rodegenerative disorder characterized by b...
Introduction. Mutations in the alpha-synuclein gene (SNCA) lead to familial forms of Parkinson's dis...
Until 4 years ago, the role of genetic factors in the aetiology of PD was controversial but subseque...
Mutations in the alpha-synuclein gene are responsible for an autosomal-dominantly inherited form of ...
α-Synuclein is considered to play an important role in the pathogenesis of both the rare famil...
Parkinson\u27s disease (PD) is a neurodegenerative disorder in which relatives of the probands are a...
We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with P...
The G209A mutation in the alpha-synuclein gene has been associated with autosomal dominant PD (ADPD)...
Introduction The pathogenesis of Parkinson’s disease (PD) involves both genetic susceptibility and e...
Genomic multiplications of the alpha-synuclein gene (SNCA) cause autosomal dominant Parkinson diseas...
In the past few years, the genetic contribution to Parkinson's disease (PD) has gained major attenti...
Introduction: Missense variants and multiplications of the alpha-synuclein gene (SNCA) are establish...
Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder. Aging, environmental fac...
Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence of approxi...
In a previous study, we detected an association between a dinucleotide repeat (Rep1) in the alpha-Sy...
Parkinson's disease (PD) is a common progressive neu-rodegenerative disorder characterized by b...
Introduction. Mutations in the alpha-synuclein gene (SNCA) lead to familial forms of Parkinson's dis...
Until 4 years ago, the role of genetic factors in the aetiology of PD was controversial but subseque...
Mutations in the alpha-synuclein gene are responsible for an autosomal-dominantly inherited form of ...
α-Synuclein is considered to play an important role in the pathogenesis of both the rare famil...
Parkinson\u27s disease (PD) is a neurodegenerative disorder in which relatives of the probands are a...
We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with P...
The G209A mutation in the alpha-synuclein gene has been associated with autosomal dominant PD (ADPD)...
Introduction The pathogenesis of Parkinson’s disease (PD) involves both genetic susceptibility and e...
Genomic multiplications of the alpha-synuclein gene (SNCA) cause autosomal dominant Parkinson diseas...
In the past few years, the genetic contribution to Parkinson's disease (PD) has gained major attenti...
Introduction: Missense variants and multiplications of the alpha-synuclein gene (SNCA) are establish...
Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder. Aging, environmental fac...