MR Imaging Biomarkers in Oncology Clinical Trials
- Abramson, Richard G.
- Arlinghaus, Lori R.
- Dula, Adrienne N.
- Quarles, C. Chad
- Stokes, Ashley M.
- Weis, Jared A.
- Whisenant, Jennifer G.
- Chekmenev, Eduard Y.
- Zhukov, Igor
- Williams, Jason M.
- Yankeelov, Thomas E.
DOIAbstract
The authors discuss eight areas of quantitative MR imaging that are currently used (RECIST, DCE-MR imaging, DSC-MR imaging, diffusion MR imaging) in clinical trials or emerging (CEST, elastography, hyperpolarized MR imaging, multiparameter MR imaging) as promising techniques in diagnosing cancer and assessing or predicting response of cancer to therapy. Illustrative applications of the techniques in the clinical setting are summarized before describing the current limitations of the methods
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