Parathyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
- Bisello, Alessandro
- Chorev, Michael
- Friedman, Peter A.
- Gardella, Tom
- Hills, Rebecca
- Jueppner, Harald
- Martin, T. John
- Nissenson, Robert A.
- Potts, Jr., John Thomas
- Silve, Caroline
- Usdin, Ted B.
- Vilardaga, Jean-Pierre
Publication date
September 2019
DOI Publisher
Edinburgh University Library Language
EnglishAbstract
The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [47]) are family B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1 receptor) is activated by precursor-derived peptides: PTH (84 amino acids), and PTHrP (141 amino-acids) and related peptides (PTH-(1-34), PTHrP-(1-36)). The parathyroid hormone 2 receptor (PTH2 receptor) is activated by the precursor-derived peptide TIP39 (39 amino acids). [125I]PTH may be used to label both PTH1 and PTH2 receptors
Add to ORKG