The use of DNA-based therapeutics requires efficient delivery systems to transport the DNA to their place of action within the cell. To accomplish this, we investigated multiwalled carbon nanotubes (pristine MWCNT, p-MWCNT) functionalized with hydroxyl groups via 1,3-dipolar cycloaddition. In this way, we have obtained MWCNT-f-OH with improved stability in aqueous dispersions which is an advantageous property for their use in cellular environments. Afterwards, a carrier strand oligodeoxynucleotide (CS-ODN) was adsorbed to MWCNT-f-OH followed by hybridization with a therapeutic antisense oligodeoxynucleotide (AS-ODN). The amount of adsorbed CS-ODN, as well as the complementary AS-ODN and a non-complementary oligodeoxynucleotide (NS-ODN) as r...
In the last few years the field of nanobiotechnology has been revolutionised with the emergence of a...
Novel hybrids of fluorescein-labeled poly(ethylene glycol)-modified single-walled carbon nanotubes ...
The use of carbon nanotubes as a gene delivery system has been extensively studied in recent years o...
The use of DNA-based therapeutics requires efficient delivery systems to transport the DNA to their ...
Background: In addition to conventional chemotherapeutics, nucleic acid-based therapeutics like anti...
The ability to bypass most cellular barriers to gain access to intracellular compartments has great ...
With the advent of molecularly targeted agents in place of the traditionally employed chemotherapeut...
PEGylated-carbon nanotubes (PNTs) were evaluated as nanocarriers of antisense oligonucleotides into ...
PEGylated-carbon nanotubes (PNTs) were evaluated as nanocarriers of antisense oligonucleotides into ...
Oligonucleotide (ODN) decoys are synthetic ODNs containing the DNA binding sequence of a transcript...
An efficient molecular delivery technique based on the transporting high-molecular-weight PEI 600K-m...
Abstract : Nanomaterials are the foundations of Nanotechnology, which are measured in nanoscales, C...
Double-walled carbon nanotubes (DWNTs) prepared by catalytic chemical vapour deposition were functio...
The present report shows that ammonium-functionalised CNTs (f-CNTs) are able to form stable complexe...
The number of cylinders that constitute a carbon nanotube (CNT) can vary from only one to several on...
In the last few years the field of nanobiotechnology has been revolutionised with the emergence of a...
Novel hybrids of fluorescein-labeled poly(ethylene glycol)-modified single-walled carbon nanotubes ...
The use of carbon nanotubes as a gene delivery system has been extensively studied in recent years o...
The use of DNA-based therapeutics requires efficient delivery systems to transport the DNA to their ...
Background: In addition to conventional chemotherapeutics, nucleic acid-based therapeutics like anti...
The ability to bypass most cellular barriers to gain access to intracellular compartments has great ...
With the advent of molecularly targeted agents in place of the traditionally employed chemotherapeut...
PEGylated-carbon nanotubes (PNTs) were evaluated as nanocarriers of antisense oligonucleotides into ...
PEGylated-carbon nanotubes (PNTs) were evaluated as nanocarriers of antisense oligonucleotides into ...
Oligonucleotide (ODN) decoys are synthetic ODNs containing the DNA binding sequence of a transcript...
An efficient molecular delivery technique based on the transporting high-molecular-weight PEI 600K-m...
Abstract : Nanomaterials are the foundations of Nanotechnology, which are measured in nanoscales, C...
Double-walled carbon nanotubes (DWNTs) prepared by catalytic chemical vapour deposition were functio...
The present report shows that ammonium-functionalised CNTs (f-CNTs) are able to form stable complexe...
The number of cylinders that constitute a carbon nanotube (CNT) can vary from only one to several on...
In the last few years the field of nanobiotechnology has been revolutionised with the emergence of a...
Novel hybrids of fluorescein-labeled poly(ethylene glycol)-modified single-walled carbon nanotubes ...
The use of carbon nanotubes as a gene delivery system has been extensively studied in recent years o...