LIFESTYLE AND OVARY FUNCTION IN YOUNG INFERTILE WOMEN

Neplodnost je nemogućnost seksualno aktivnog para, koji ne koristi kontracepcijske metode, da postigne spontanu trudnoću unutar jedne godine ciljanih spolnih odnosa. Danas sve više mladih parova traži medicinsku pomoć za začeće ali u prosjeku nakon značajno dužeg vremena nego što je to preporučeno. Htjeli smo istražiti koji su to mogući problemi reprodukcije kod mlađih žena do 35. godine. Osnovni cilj rada bio je dokazati kako životni stil i navike utječu na funkciju jajnika u reprodukcijski mlađoj dobnoj skupini. Ispitanice su dobrovoljno ispunjavale anonimnu online anketu. Istraživanjem su bile obuhvaćene žene do 35 godina koje su liječene postupcima medicinski pomognute oplodnje. Ispitivale su se njihove prehrambene navike, indeks tjelesne mase, menstruacijski ciklus te vrijednosti hormona u krvi i detalji iz postupaka medicinski pomognute oplodnje. Najvažniji uvjet kod ispunjavanja ankete je bio da imaju izvađene hormone 3. – 5. dan ciklusa koje su vadile na samom početku liječenja postupcima medicinski pomognute oplodnje. Nije utvrđena značajna razlika u vrijednostima hormona (LH, TSH, prolaktina,testosterona i Anti Müllerovog hormona) u odnosu na uhranjenost ispitanica - ITM. Značajno su niže vrijednosti FSH u ispitanica koje su pothranjene u odnosu na normalno uhranjene. Vrijednosti estradiola su značajno manje u pretilih ispitanica u odnosu na normalno uhranjene ispitanice (65 vs. 256,29 (pmol/L). Značajno niže vrijednosti anti Müllerova hormona imaju ispitanice koje su prvu mjesečnicu dobile ranije (10 – 12 godina) i one s kraćim menstruacijskim ciklusom (20 – 25 dana). Anti Mullerov hormon je značajno niži u ispitanica čije su majke imale rani nastup menopauze, što može predskazati rani nastup menopauze u ispitanica. Kasniji nastup menopauze u majki, povezan je sa značajno većom vrijednošću Anti Mullerovog hormona u njihovih kćeri. Ostali hormoni nisu značajno povezani s nastupom menopauze u majki ispitanica.Infertility is the inability of a sexually active couple, who do not use contraceptive methods, to achieve a spontaneous pregnancy within one year of targeted sexual intercourse. Today, more and more young couples are seeking medical help to produce offspring but on average after twice as long as recommended. With this paper, we wanted to see what are the problems of today with younger women up to the age of 35. The main aim of the study was to prove how lifestyle and habits affect ovarian function in the reproductively younger age group. An anonymous online survey was conducted where women up to the age of 35 who underwent assisted reproductive technology were affected. Their eating habits, body mass index, menstrual cycle, and hormones and details from infertility treatment were examined. The most important condition in completing the survey was that they had hormones taken out on the 3rd - 5th day of the cycle, which they extracted at the beginning of treatment with assisted reproductive technology. No significant difference was found in the values of hormones (LH, TSH, prolactin, testosterone and Anti Müller hormone) in relation to the nutrition of the subjects (BMI). Significantly lower FSH values in the subject who were malnourished compared to normally fed. Estradiol values are significantly lower in obese subjects compared to normally fed subjects (65 versus 256.29 (pmol / L) .Significantly lower values of anti- Müller hormone have the test that received the first monthly earlier (10 - 12 years) and those with shorter menstrual cycle (20 - 25 days) Anti-Muller's hormone is significantly lower in subjects whose mothers had early menopause, which may predict early onset of menopause in the subject. Later onset of menopause in mothers is associated with a significant majority of Anti-Muller's hormone Other hormones are not significantly associated with the onset of menopause in the maternal subject