JC virus as a marker of human migration to the Americas

Fil: Stoner, Gerald L. National Institutes of Health. National Institute of Neurological Disorders and Stroke. Neurotoxicology Section, Bethesda, Maryland; Estados Unidos.Fil: Jobes, David V. National Institutes of Health. National Institute of Neurological Disorders and Stroke. Neurotoxicology Section, Bethesda, Maryland; Estados Unidos.Fil: Fernández Cobo, Mariana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Servicio de Biología Molecular; Argentina.Fil: Agostini, Hansjürgen T. University of Freiburg. Department of Ophthalmology; Alemania.Fil: Chima, Sylvester C. National Institutes of Health. National Institute of Neurological Disorders and Stroke. Neurotoxicology Section, Bethesda, Maryland; Estados Unidos.Fil: Ryschkewitsch, Caroline F. National Institutes of Health. National Institute of Neurological Disorders and Stroke. Neurotoxicology Section, Bethesda, Maryland; Estados Unidos.JC virus is a ubiquitous human polyomavirus present in populations worldwide. Seven genotypes differing in DNA sequence by approximately 1-3% characterize three Old World population groups (African, European and Asian) as well as Oceania. It is possible to follow Old World populations into the New World by the JC virus genotypes they carried. The first population to settle in the Americas, the Native Americans, brought with them type 2A from northeast Asia. European settlers arriving after Columbus carried primarily type 1 and type 4. Africans brought by the slave trade carried type 3 and type 6