Evaluation of the in vitro activity of amphotericin B by time-kill curve methodology against large and small capsulate C. neoformans isolates

Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micologia; Argentina.Fil: Afeltra, Javier. Hospital Dr. José María Ramos Mejía. Micologia. Unidad de Parasitologia; Argentina.Fil: Vitale, Roxana G. Hospital Dr. José María Ramos Mejía. Micologia. Unidad de Parasitologia; Argentina.We have evaluated and compared the activity of amphotericin B (AMB) by time-kill curve methodology against 20 clinical Cryptococcus neoformans isolates in which capsule induction in vitro was performed. Overall, large capsulated isolates were more resistant to killing by AMB over time when compared with those small capsulate ones