Clinical features and outcomes of 124 pregnant women hospitalized with COVID-19: a prospective observational study.

ABSTRACT : Objectives: pregnancy is known to worsen the clinical course of COVID-19 compared to non-pregnant women of the same age. The aim of this study is to evaluate maternofetal and neonatal clinical features and outcomes of pregnant women with COVID-19. Material and methods: For this prospective single-center study, data of 124 pregnant women who were hospitalized and treated for COVID-19 between April 20, 2020 and March 20, 2021 were collected. Clinical, laboratory and obstetric characteristics of pregnant women during hospitalization were recorded. Results: 61% of pregnant women were symptomatic while hospitalized. Nine of the pregnant women were admitted to the intensive care unit, 4 required invasive mechanical ventilation, and two died during the hospitalization associated with COVID-19. Abortion occurred in 3 pregnant women. As maternofetal outcomes, 18% of pregnant women had preterm labor and 10% had fetal distress. The PCR test of 46 pregnant women was positive during delivery, and the PCR test of 37 pregnant women was negative. NICU was required in 19% of newborns. COVID-19 PCR was positive in 2 newborns. Non-COVID-19 related death was observed in 1 premature newborn. Conclusions: Pregnancies complicated by COVID-19 infection should be followed closely due to the risk of adverse maternal and fetal outcomes.