Iridium(I)-Catalyzed Alkylation Reactions to Form ?-Alkylated Ketones

PubMed: 294320022-s2.0-85042858918A highly effective and green procedure for the formation of ?-alkylated ketones has been disclosed via the reaction of primary alcohols with secondary alcohols and ketones by using [IrCl(COD)(NHC)] complexes as a catalyst. Various ?-alkylated ketones were obtained in high yields from the alkylation of alcohol with alcohol and ketone with alcohol through a borrowing hydrogen reaction by using 0.05-0.5 mol % iridium(I) and a catalytic amount of KOH (5-10 mol %) as the base under air atmosphere and within very short reaction times. © 2018 American Chemical Society