REVIEW OF ANTIHYPERTENSIVE ACTIVITIES OF THREE SPECIES OF ZINGIBERACEAE

Objective: The purpose of this study was aimed to review the antihypertensive activities of 3 plant species from the Familia Zingiberaceae. Methods: This review examined the antihypertensive activities by obtaining data from primary, secondary, and tertiary articles on journal sites such as Google Scholar, PubMed, Wiley Online Library, Elsevier, Springer, ResearchGate with a maximum publication of 10 y and contains relevant bibliographies. Results: Literature studies has shown that white ginger (Zingiber officinale Roscoe) is clinically effective as an antihypertensive agent by lowering systolic blood pressure and serum sICAM-1 concentration. Furthermore, the in vivo administration lowers the blood pressure in the arteries of anesthetized rats while in vitro demonstrated a dose-dependent ACE inhibitory activity. Curcuma javanica (Curcuma xanthorrhiza Roxb) also has a similar effect with changes in the respondent's systolic and diastolic blood pressure, and when administered in vivo, it reduces renin levels in the adjuvant captopril group than the negative control group while in vitro administration showed high ACE inhibitory activity. Aromatic ginger (Kaempferia galanga L) administered in vivo lowered the basal arterial pressure (MAP) and increased diuretic activity depending on the urine volume dose and the excretion of Na+and K+. Conclusion: Based on the results, plants in the Zingiberaceae family, namely white ginger (Zingiber officinale Roscoe), Curcuma javanica (Curcuma xanthorrhiza Roxb), and aromatic ginger (Kaempferia galanga L) have antihypertensive activities clinically, in vivo, and in vitro