Origin and Global Expansion of Complex Lineage 3.
- Shuaib, Yassir A
- Utpatel, Christian
- Kohl, Thomas A
- Barilar, Ivan
- Diricks, Margo
- Ashraf, Nadia
- Wieler, Lothar H
- Kerubo, Glennah
- Mesfin, Eyob A
- Diallo, Awa Ba
- Al-Hajoj, Sahal
- Ndung'u, Perpetua
- Fitzgibbon, Margaret M
- Vaziri, Farzam
- Sintchenko, Vitali
- Martinez, Elena
- Viegas, Sofia O
- Zhou, Yang
- Azmy, Aya
- Al-Amry, Khaled
- Godreuil, Sylvain
- Varma-Basil, Mandira
- Narang, Anshika
- Ali, Solomon
- Beckert, Patrick
- Dreyer, Viola
- Kabwe, Mwila
- Bates, Matthew
- Hoelscher, Michael
- Rachow, Andrea
- Gori, Andrea
- Tekwu, Emmanuel M
- Sidze, Larissa K
- Jean-Paul, Assam A
- Beng, Veronique P
- Ntoumi, Francine
- Frank, Matthias
- Diallo, Aissatou Gaye
- Mboup, Souleymane
- Tessema, Belay
- Beyene, Dereje
- Khan, Sadiq N
- Diel, Roland
- Supply, Philip
- Maurer, Florian P
- Hoffmann, Harald
- Niemann, Stefan
- Merker, Matthias
DOIAbstract
complex (MTBC) Lineage 3 (L3) strains are abundant in world regions with the highest tuberculosis burden. To investigate the population structure and the global diversity of this major lineage, we analyzed a dataset comprising 2682 L3 strains from 38 countries over 5 continents, by employing 24-loci mycobacterial interspersed repetitive unit-variable number of tandem repeats genotyping (MIRU-VNTR) and drug susceptibility testing. We further combined whole-genome sequencing (WGS) and phylogeographic analysis for 373 strains representing the global L3 genetic diversity. Ancestral state reconstruction confirmed that the origin of L3 strains is located in Southern Asia and further revealed multiple independent introduction events into North-Eas...
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