Protein Kinase B (PKB), also known as Akt, was discovered in 1991 as the mammalian homologue of the viral oncogene product, v-akt. Subsequently, overexpression or constitutive activation of PKBα, PKBβ and PKBγ has been demonstrated in a number of cancers. The idea that inhibition of PKB in cancer cells may restore the sensitivity of cells to chemotherapeutic drugs has fuelled the search for specific inhibitors of PKB. The aim was to manipulate PKB levels by overexpression or antisense technology to determine whether PKB regulates apoptosis. To test whether various PKB isoforms have the potential to regulate apoptosis in cells PKB levels were first modulated by overexpression. For this the activation of caspase-3 by staurosporine, an establi...
The AKT or PKB family of protein kinases is one of the best characterized targets of phosphoinositid...
The AKT or PKB family of protein kinases is one of the best characterized targets of phosphoinositid...
Cardiovascular disease is the most common cause of death worldwide and therefore it belongs to one o...
Protein kinase B (PKB, also called Akt) is an important regulator of cell proliferation and survival...
Breast cancer is the most common cancer in women and is increasing in both the developed and develop...
Cancer is the result of a disturbed balance between cell division and growth on one hand, and progra...
Cancer is the result of a disturbed balance between cell division and growth on one hand, and progra...
One of the most important roles for growth factors such as insulin and IGF-1 in certain cells is the...
Protein kinase B appears to play a key role in insulin signaling and in the control of apoptosis, al...
The study of cell signalling is important in elucidating the roles of many proteins in cellular func...
Akt (also known as protein kinase B or PKB) is the major downstream nodal point of the PI3K signalin...
Akt/PKB (protein kinase B) is a serine-threonine kinase involved in the regulation of many cellular ...
Full activation of protein kinase B (PKB, also called Akt) requires phosphorylation on two regulator...
ABSTRACT: We describe a novel, potent peptide substrate mimetic inhibitor of protein kinase B (PKB/ ...
The AKT or PKB family of protein kinases is one of the best characterized targets of phosphoinositid...
The AKT or PKB family of protein kinases is one of the best characterized targets of phosphoinositid...
The AKT or PKB family of protein kinases is one of the best characterized targets of phosphoinositid...
Cardiovascular disease is the most common cause of death worldwide and therefore it belongs to one o...
Protein kinase B (PKB, also called Akt) is an important regulator of cell proliferation and survival...
Breast cancer is the most common cancer in women and is increasing in both the developed and develop...
Cancer is the result of a disturbed balance between cell division and growth on one hand, and progra...
Cancer is the result of a disturbed balance between cell division and growth on one hand, and progra...
One of the most important roles for growth factors such as insulin and IGF-1 in certain cells is the...
Protein kinase B appears to play a key role in insulin signaling and in the control of apoptosis, al...
The study of cell signalling is important in elucidating the roles of many proteins in cellular func...
Akt (also known as protein kinase B or PKB) is the major downstream nodal point of the PI3K signalin...
Akt/PKB (protein kinase B) is a serine-threonine kinase involved in the regulation of many cellular ...
Full activation of protein kinase B (PKB, also called Akt) requires phosphorylation on two regulator...
ABSTRACT: We describe a novel, potent peptide substrate mimetic inhibitor of protein kinase B (PKB/ ...
The AKT or PKB family of protein kinases is one of the best characterized targets of phosphoinositid...
The AKT or PKB family of protein kinases is one of the best characterized targets of phosphoinositid...
The AKT or PKB family of protein kinases is one of the best characterized targets of phosphoinositid...
Cardiovascular disease is the most common cause of death worldwide and therefore it belongs to one o...