Much of my book Philosophy of Psychedelics is devoted to elaborating and defending two basic claims: that psychedelic therapy works mainly by changing mental representations of the self, and that it has many epistemic benefits consistent with a naturalistic worldview. The commentaries in this symposium generally focus on one or the other of these claims. On the mechanistic front, the commentaries by Hoffman and by Martin and Sterzer seek to supplement my account by drawing attention to factors it does not emphasize. In this reply I agree with most of their claims, but propose some important qualifications. Meanwhile, the commentaries by Lyon and Farrenikova and by Colombo challenge some core commitments of my account. I agree with many of t...