Trypanosoma cruzi diversity in the Gran Chaco: Mixed infections and differential host distribution of TcV and TcVI
- Monje Rumi, Maria Mercedes
- Perez Brandan, Cecilia Maria
- Ragone, Paula Gabriela
- Tomasini, Nicolás
- Lauthier, Juan José
- Alberti D'Amato, Anahi M.
- Cimino, Ruben O.
- Orellana, Viviana
- Basombrio, Miguel Angel Manuel
- Diosque, Patricio
DOIAbstract
The transmission cycles of Trypanosoma cruzi in the Gran Chaco are complex networks involving domestic and wild components, whose interrelationships are not well understood. Knowing the circuit of transmission of the different Discrete Typing Units (DTUs) of T. cruzi in the complex environment of the Chaco region is relevant to understanding how the different components (reservoirs, vectors, ecotopes) interact. In the present study we identified the DTUs infecting humans and dogs in two rural areas of the Gran Chaco in Argentina, using molecular methods which avoid parasite culture. Blood samples of humans and dogs were typified by PCR-DNA blotting and hybridization assays with five specific DNA probes (TcI, TcII, TcIII, TcV and TcVI). PCR ...
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