Comparative plasma exposure of albendazole after administration of rapid disintegrating tablets in dogs
- Castro, Silvina Gabriela
- Dib, Alicia
- Suarez, Gonzalo
- Allemandi, Daniel Alberto
- Lanusse, Carlos Edmundo
- Sanchez Bruni, Sergio Fabian
- Palma, Santiago Daniel
DOIAbstract
The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.Fil: Castro, Silvina Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnol...
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