Characterization of a type O foot-and-mouth disease virus re-emerging in the year 2011 in free areas of the Southern Cone of South America and cross-protection studies with the vaccine strain in use in the region
- Maradei, Eduardo
- Malirat, Viviana
- Perez Beascoechea, Claudia
- Oviedo Benitez, Elizabeth
- Pedemonte, Andrea
- Seki, Cristina
- Galdo Novo, Sabrina
- Balette, Cristina
- D'aloia, Ricardo
- la Torre, Jose Leonardo
- Mattion, Nora Marta
- Rodriguez Toledo, Jorge
- Bergmann, Ingrid Evelyn
DOIAbstract
Molecular, antigenic and vaccine matching studies, including protective response in vivo,were conducted with a foot-and-mouth disease type O virus isolated during the outbreak in September 2011 in San Pedro, Paraguay, country internationally recognized as free with vaccination in 1997. The phylogenetic tree derived from complete VP1 sequences as well as monoclonal antibody profiling indicated that this isolate was related to viruses responsible for previous emergencies in free areas of the Southern Cone of South America occurring sporadically between the years 2000 and 2006. Marked differences with the vaccine strain O1/Campos, including the loss of reactivity with neutralizing MAbs, were recognized. Levels of protective antibodies induced...
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