Synthesis of heterocyclic bis-amides derivatives through four-component condensation Ugi reaction.

This project focuses on a multicomponent reaction, Ugi; which is a four-component condensation reaction. Each of these reactions will utilize an aldehyde or ketone moiety, an amine, an isonitrile, and a carboxylic acid resulting in derivatives of bis-amides. In this project, we will target various derivatives of heterocyclic aromatic aldehydes to synthesize biologically active Ugi derivatives. Previous research has shown it to help with the treatment of illnesses like multiple myeloma, anti-malarial, anti-cancer, and antiproliferative treatments. All reactants will be successively (Aniline, an Aldehyde, Benzoic Acid, and Cyclohexylisocyanide) mixed together into a 10 mL microwave vial with a magnetic stirring bar. The mixture will be heated at 45℃ for 30 minutes at a power of 200W. Our hypothesis is not only we will get good yields and a faster rate of reaction, but the cleaning procedure will be very feasible because the final product results as a solid product that can be purified by the recrystallization procedure. The completion of the reaction will be monitored by Thin Layer Chromatography (TLC) and can be characterized by NMR (Nuclear Magnetic Resonance Spectroscopy) and Melting Point. The major goal of synthesizing this material is not only providing a novel methodology to the research community but also utilizing the derivatives to test as anti-cancer drugs in-vitro and in-vitro studies