International audienceA new method to reconstruct past climatic conditions between 130 and 100 ka BP from pollen and isotopic data is applied to a previously unanalyzed Grande Pile core, GPXXI. We applied the inverse mode to the Biome4 vegetation model. The method utilizes delta C-13, measured in parallel to the pollen samples as a constraint for the model. First the biomes and the delta C-13 simulated by the model are compared with the biome allocation of the pollen data. The delta C-13 to be simulated takes into account the degradation effect on the preserved organic matter. This procedure allows the reconstruction of the mean annual temperature and precipitation as well as the mean temperatures of the warmest and coldest months. We show ...