Modern approaches in the biological therapy of the anterior ocular surface

Aim: The aim of this article is to analyze and summarize the current literature on the use of autologous serum eye drops for ocular surface disorders in the last 10 years and to evaluate their potential therapeutic advantages.Materials and Methods: А research in the electronic database PubMed for a 10-year period (November, 2011–November, 2021) has been performed. A combination of following keywords has been used: “blood”, “serum”, “eye drops”, “ocular surface disease”. In addition, referent lists of the most suitable articles have been checked in order to identify acceptable materials, which have not been covered by the initial literature research. Publications in English and full-text only have been selected.Results: A total of 51 articles with the aforementioned keywords have been found. The full text of 28 of them, corresponding to the inclusion criteria, has been revised. Fourteen articles about appliance of serum eye drops for ocular surface disorders have been found; 2 articles about the use of drops from platelet-derived products, 4 with appliance of umbilical cord blood serum eye drops, 7 comparing the effectiveness between three types of blood derivatives and conventional therapy, and 1 review of the literature. Conclusion: Use of blood products for treatment of ocular surface disorders has had growing popularity in the last years due to their good safety profile and effectivity. For their implementation in everyday clinical practice, more randomized clinical trials and internationally admitted guidelines are needed