Necroptosis—an inflammatory mode of cell death

Introduction: Cell death is a key mechanism involved in the development of any organism and the maintenance of tissue homeostasis throughout life. In recent years, the discovery of new forms of necrosis has challenged the traditional concept of apoptosis and necrosis as the two main modes of cell death. Necroptosis is the best studied form of regulated necrosis. It has morphological characteristics of passive necrosis, but similar to apoptosis is strictly regulated by the intracellular protein platform. As lytic cell death, necroptosis causes rapid destruction of the cell membrane, leading to the release of intracellular molecules that activate the immune response and initiate inflammation. Thus, necroptosis is considered a pro-inflammatory model of cell death, involving it in the etiology and pathogenesis of many disease states.Aim: The aim of the present study was to review literature data on the role of necroptosis in the development of inflammation.Materials and Methods: For the period 2000–2022 in the available databases (Scopus, ScienceDirect, Web of Science, Access Medicine, PubMed) the following keywords were used in English: cell death, apoptosis, necrosis, regulated necrosis, necroptosis, DAMPs, inflammation.Results: A total of 5,514 publications were found, of which 2,031 were review articles, book chapters and 3,483 publications, as a result of research, abstracts, posters and other communications. Studies of the literature have shown that necroptosis acts as an inducer of inflammation by releasing DAMPs