BACKGROUND: The EXPEDITION study addressed the efficacy and safety of inhibiting the sodium hydrogen exchanger isoform-1 (NHE-1) by cariporide in the prevention of death or myocardial infarction (MI) in patients undergoing coronary artery bypass graft surgery. The premise was that inhibition of NHE-1 limits intracellcular Na accumulation and thereby limits Na/Ca-exchanger-mediated calcium overload to reduce infarct size. METHODS: High-risk coronary artery bypass graft surgery patients (n = 5,761) were randomly allocated to receive either intravenous cariporide (180 mg in a 1-hour preoperative loading dose, then 40 mg per hour over 24 hours and 20 mg per hour over the subsequent 24 hours) or placebo. The primary composite endpoint of death o...
The concept of electrical protection of the ischemic myocardium is in constant evolution and has rec...
This study was designed to determine the potential therapeutic effects of a new sodium-hydrogen exch...
Background and Aims: Acute kidney injury (AKI) following cardiac surgery is a major complication res...
BACKGROUND: The EXPEDITION study addressed the efficacy and safety of inhibiting the sodium hydrogen...
Background. The EXPEDITION study addressed the efficacy and safety of inhibiting the sodium hydrogen...
Objectives: To evaluate the effects of cariporide on all-cause mortality or myocardial infarction at...
AbstractObjectivesTo evaluate the effects of cariporide on all-cause mortality or myocardial infarct...
Background—The transmembrane sodium/hydrogen exchanger maintains myocardial cell pH integrity during...
AbstractObjectives: The preconditioning effects of the adjunctive, cardiac-specific sodium-hydrogen ...
International audienceCariporide, an Na/H exchanger inhibitor, is a drug with cardioprotective prope...
AbstractOBJECTIVESWe conducted an international, prospective, randomized, double-blind, placebo-cont...
International audienceThis study investigated the effects of cariporide, an inhibitor of sodium-prot...
International audienceHyperglycemia encountered during diabetes triggers abnormalities of vascular f...
AbstractObjective: We sought to determine whether pretreatment with a sodium/hydrogen-exchange inhib...
AbstractBackgroundReperfusion therapy limits infarct size and improves survival in patients with ST-...
The concept of electrical protection of the ischemic myocardium is in constant evolution and has rec...
This study was designed to determine the potential therapeutic effects of a new sodium-hydrogen exch...
Background and Aims: Acute kidney injury (AKI) following cardiac surgery is a major complication res...
BACKGROUND: The EXPEDITION study addressed the efficacy and safety of inhibiting the sodium hydrogen...
Background. The EXPEDITION study addressed the efficacy and safety of inhibiting the sodium hydrogen...
Objectives: To evaluate the effects of cariporide on all-cause mortality or myocardial infarction at...
AbstractObjectivesTo evaluate the effects of cariporide on all-cause mortality or myocardial infarct...
Background—The transmembrane sodium/hydrogen exchanger maintains myocardial cell pH integrity during...
AbstractObjectives: The preconditioning effects of the adjunctive, cardiac-specific sodium-hydrogen ...
International audienceCariporide, an Na/H exchanger inhibitor, is a drug with cardioprotective prope...
AbstractOBJECTIVESWe conducted an international, prospective, randomized, double-blind, placebo-cont...
International audienceThis study investigated the effects of cariporide, an inhibitor of sodium-prot...
International audienceHyperglycemia encountered during diabetes triggers abnormalities of vascular f...
AbstractObjective: We sought to determine whether pretreatment with a sodium/hydrogen-exchange inhib...
AbstractBackgroundReperfusion therapy limits infarct size and improves survival in patients with ST-...
The concept of electrical protection of the ischemic myocardium is in constant evolution and has rec...
This study was designed to determine the potential therapeutic effects of a new sodium-hydrogen exch...
Background and Aims: Acute kidney injury (AKI) following cardiac surgery is a major complication res...