International audienceA vaccine against heterosexual transmission by human immunodeficiency virus (HIV) should generate cytotoxic and antibody responses in the female genital tract and in extra-genital organs. We report that sublingual immunization with HIV-1 gp41 and a reverse transcriptase polypeptide coupled to the cholera toxin B subunit (CTB) induced gp41-specific IgA antibodies and antibody-secreting cells, as well as reverse transcriptase-specific CD8 T cells in the genital mucosa, contrary to intradermal immunization. Conjugation of the reverse transcriptase peptide to CTB favored its cross-presentation by human dendritic cells to a T cell line from an HIV(+) patient. Sublingual vaccination could represent a promising vaccine strate...
Aims: With the overall objective to guide future vaccination efforts against sexually transmitted an...
We evaluated changes in global and human immunodeficiency virus (HIV)–specific genital T cells after...
The human immunodeficiency virus (HIV) burden in women continues to increase, and heterosexual conta...
International audienceA vaccine against heterosexual transmission by human immunodeficiency virus (H...
International audiencePersistent B cell responses in mucosal tissues are crucial to control infectio...
We have recently reported that the sublingual (s.l.) mucosa is an efficient site for inducing system...
Development of a vaccine that can elicit robust HIV specific antibody responses in the mucosal compa...
© 2016 Dr. Hyon Xhi TanMore than 36 million people were infected with the human immunodeficiency vir...
The genital mucosa is the main site of initial human immunodeficiency virus type 1 (HIV-1) contact w...
International audienceClin Microbiol Infect 2012; 18 (Suppl. 5): 1-6 ABSTRACT: The female genital mu...
The oral mucosa is an attractive site for mucosal vaccination, however the thick squamous epithelium...
AbstractThe female genital mucosa constitutes the major port of entry of sexually transmitted infect...
Control of pandemic human immunodeficiency virus type 1 (HIV-1) infection ideally requires specific ...
<div><p>Induction of local antiviral immune responses at the mucosal portal surfaces where HIV-1 and...
HIV mutates rapidly and infects CD4+ T cells, especially when they are activated. A vaccine targetin...
Aims: With the overall objective to guide future vaccination efforts against sexually transmitted an...
We evaluated changes in global and human immunodeficiency virus (HIV)–specific genital T cells after...
The human immunodeficiency virus (HIV) burden in women continues to increase, and heterosexual conta...
International audienceA vaccine against heterosexual transmission by human immunodeficiency virus (H...
International audiencePersistent B cell responses in mucosal tissues are crucial to control infectio...
We have recently reported that the sublingual (s.l.) mucosa is an efficient site for inducing system...
Development of a vaccine that can elicit robust HIV specific antibody responses in the mucosal compa...
© 2016 Dr. Hyon Xhi TanMore than 36 million people were infected with the human immunodeficiency vir...
The genital mucosa is the main site of initial human immunodeficiency virus type 1 (HIV-1) contact w...
International audienceClin Microbiol Infect 2012; 18 (Suppl. 5): 1-6 ABSTRACT: The female genital mu...
The oral mucosa is an attractive site for mucosal vaccination, however the thick squamous epithelium...
AbstractThe female genital mucosa constitutes the major port of entry of sexually transmitted infect...
Control of pandemic human immunodeficiency virus type 1 (HIV-1) infection ideally requires specific ...
<div><p>Induction of local antiviral immune responses at the mucosal portal surfaces where HIV-1 and...
HIV mutates rapidly and infects CD4+ T cells, especially when they are activated. A vaccine targetin...
Aims: With the overall objective to guide future vaccination efforts against sexually transmitted an...
We evaluated changes in global and human immunodeficiency virus (HIV)–specific genital T cells after...
The human immunodeficiency virus (HIV) burden in women continues to increase, and heterosexual conta...