Directed Studies Towards The Total Synthesis of (+)-13-Deoxytedanolide: Simple and Convenient Synthesis of C8-C16 Fragment

International audienceA straightforward synthesis of the enantioenriched C8-C16 south part of (+)-13-deoxytedanolide has been reported. The strength of this approach relies on the preparation of similar functionalized fragments via the transformation of a unique dihydrofuran building block through a 1,2-metallate rearrangement