Aims/hypothesis Our aims were to compare osteoclastic activity between patients with acute Charcot’s osteoarthropathy and diabetic and healthy controls, and to determine the effect of the receptor activator of nuclear factor-kappaB ligand (RANKL) and its decoy receptor osteoprotegerin (OPG). Methods Peripheral blood monocytes isolated from nine diabetic Charcot patients, eight diabetic control and eight healthy control participants were cultured in the presence of macrophage-colony stimulating factor (M-CSF) alone, M-CSF and RANKL, and also M-CSF and RANKL with excess concentrations of OPG. Osteoclast formation was assessed by expression of tartrate-resistant acid phosphatase on glass coverslips and resorption on dentine slices. Results In ...
The discovery of receptor activator for nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OP...
RANKL (receptor activator of NF-kappaB ligand) induces osteoclastogenesis by activating multiple sig...
Crohn's disease (CD) is associated with low bone mass due to chronic inflammation and other factors....
Aims/hypothesis: Our aims were to compare osteoclastic activity between patients with acute Charcot'...
AIMS/HYPOTHESIS: Our aims were to compare osteoclastic activity between patients with acute Charcot'...
AIMS/HYPOTHESIS: Our aims were to compare osteoclastic activity between patients with acute Charco...
We hypothesised that tumour necrosis factor-α (TNF-α) may enhance receptor activator of nuclear fact...
AbstractOsteoprotegerin (OPG) is a decoy receptor for receptor activator of nuclear factor κB ligand...
Introduction. The receptor activator of nuclear factor-kB (RANK), ligand (RANK-L) and osteoprotegeri...
Pathological osteolyses are considered a consequence of a disturbance in the mechanisms that govern ...
Charcot Foot (CF), part of a broader condition known as Charcot Neuro-Osteoarthropathy (CNO), is cha...
Various osteotropic agents that influence bone resorption are known to act primarily via osteoblasts...
Objective: Osteoclasts are bone-resorbing multinucleated cells derived from the monocyte/macrophage ...
AbstractSeveral bone resorptive stimuli affect osteoclasts indirectly by modulating the production a...
© 2001 British Society for RheumatologyObjective. This study investigated the involvement of the rec...
The discovery of receptor activator for nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OP...
RANKL (receptor activator of NF-kappaB ligand) induces osteoclastogenesis by activating multiple sig...
Crohn's disease (CD) is associated with low bone mass due to chronic inflammation and other factors....
Aims/hypothesis: Our aims were to compare osteoclastic activity between patients with acute Charcot'...
AIMS/HYPOTHESIS: Our aims were to compare osteoclastic activity between patients with acute Charcot'...
AIMS/HYPOTHESIS: Our aims were to compare osteoclastic activity between patients with acute Charco...
We hypothesised that tumour necrosis factor-α (TNF-α) may enhance receptor activator of nuclear fact...
AbstractOsteoprotegerin (OPG) is a decoy receptor for receptor activator of nuclear factor κB ligand...
Introduction. The receptor activator of nuclear factor-kB (RANK), ligand (RANK-L) and osteoprotegeri...
Pathological osteolyses are considered a consequence of a disturbance in the mechanisms that govern ...
Charcot Foot (CF), part of a broader condition known as Charcot Neuro-Osteoarthropathy (CNO), is cha...
Various osteotropic agents that influence bone resorption are known to act primarily via osteoblasts...
Objective: Osteoclasts are bone-resorbing multinucleated cells derived from the monocyte/macrophage ...
AbstractSeveral bone resorptive stimuli affect osteoclasts indirectly by modulating the production a...
© 2001 British Society for RheumatologyObjective. This study investigated the involvement of the rec...
The discovery of receptor activator for nuclear factor kappaB ligand (RANKL) and osteoprotegerin (OP...
RANKL (receptor activator of NF-kappaB ligand) induces osteoclastogenesis by activating multiple sig...
Crohn's disease (CD) is associated with low bone mass due to chronic inflammation and other factors....