Dissection of Protein-Protein Interaction and CDK4 Inhibition in the Oncogenic versus Tumor Suppressing Functions of Gankyrin and P16

Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism

Tevelev, A

[[sponsorship]]基因體研究中心,生物化學研究所[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/g...

Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a

Baumgartner, Roland
Fernandez-Catalan, Carlos
Winoto, Astar
Huber, Robert
Engh, Richard A
Holak, Tad A

October 1998

AbstractBackground: The four members of the INK4 gene family (p16INK4a, p15INK4b, p18INK4c and p19IN...

Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a

Baumgartner, Roland
Fernandez-Catalan, Carlos
Winoto, Astar
Huber, Robert
Engh, Richard A
Holak, Tad A

October 1998

AbstractBackground: The four members of the INK4 gene family (p16INK4a, p15INK4b, p18INK4c and p19IN...

Dissection of Protein-Protein Interaction and CDK4 Inhibition in the Oncogenic versus Tumor Suppressing Functions of Gankyrin and P16

Mahajan, A

[[sponsorship]]基因體研究中心,生物化學研究所[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/g...

Structure-function studies and in silico drug discovery targeting the liver Oncoprotein Gankyrin.

Murchland, Iain

January 2013

Gankyrin is an ankyrin repeat protein known for its oncogenic effects and its up-regulation in the e...

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.

Chattopadhyay, Anasuya
O'Connor, Cornelius J
Zhang, Fengzhi
Galvagnion, Celine
Galloway, Warren
Tan, Yaw Sing
Stokes, Jamie E
Rahman, Md Taufiq
Verma, Chandra
Spring, David
Itzhaki, Laura

April 2016

Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the developmen...

Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte ProliferationSummary

Amber M. D’Souza
Yanjun Jiang
Ashley Cast
Leila Valanejad
Mary Wright
Kyle Lewis
Meenasri Kumbaji
Sheeniza Shah
David Smithrud
Rebekah Karns
Soona Shin
Nikolai Timchenko

January 2018

Background & Aims: Uncontrolled liver proliferation is a key characteristic of liver cancer; however...

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4

Byeon, IJ

[[sponsorship]]基因體研究中心,生物化學研究所[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/g...

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4

Byeon, I. J.

[[sponsorship]]基因體研究中心,生物化學研究所[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/g...

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

Chattopadhyay, Anasuya
O’Connor, Cornelius J.
Zhang, Fengzhi
Galvagnion, Celine
Galloway, Warren R. J. D.
Tan, Yaw Sing
Stokes, Jamie E.
Rahman, Taufiq
Verma, Chandra
Spring, David R.
Itzhaki, Laura S.

January 2016

Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the developmen...

The crystal structure of Gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53

Krzywda, S.
Brzozowski, A.M.
Higashitsuji, H.
Fujita, J.
Welchman, R.
Dawson, S.
Mayer, R.J.
Wilkinson, A.J.

October 2003

Gankyrin is a 25-kDa hepatocellular carcinoma-associated protein that mediates protein-protein inter...

Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome*

Dawson, Simon
Apcher, Sebastien
Mee, Maureen
Higashitsuji, Hiroaki
Baker, Rohan
Uhle, Stefan
Dubiel, Wolfgang
Fujita, Jun
Mayer, R. John

December 2015

A yeast two-hybrid screen with the human S6 (TBP7, RPT3) ATPase of the 26 S proteasome has identifie...

Solution Structure of the Human Oncogenic Protein Gankyrin Containing Seven Ankyrin Repeats and Analysis of Its Structure-Function Relationship†,‡

January 2004

ABSTRACT: Human gankyrin (226 residues, 24.4 kDa) is a liver oncoprotein that plays an important rol...

Construction & Cloning of Wild Type & Mutant (ΔN307- ΔN313) Alleles of p16ink4a

Qurat-Ul-Ain (Scholar)
Khurshid.I.Andrabi (Guide)

January 2012

p16INK4a, a CDK4/CDK6 binding protein is an established tumour suppressor implicated in cell cycle r...

P16Ink4a tumor suppressor function in lung cancer cells involves cyclin-dependent kinase 2 inhibition by Cip/Kip protein redistribution. Cell Growth Differ. 11:507–515

Bryn Grimison
Thomas A. Langan
Robert A. Sclafani

January 2000

As cell cycle regulators whose activity is frequently altered in human cancers, cyclin-dependent kin...

Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism

Tevelev, A

[[sponsorship]]基因體研究中心,生物化學研究所[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/g...

Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a

Baumgartner, Roland
Fernandez-Catalan, Carlos
Winoto, Astar
Huber, Robert
Engh, Richard A
Holak, Tad A

October 1998

AbstractBackground: The four members of the INK4 gene family (p16INK4a, p15INK4b, p18INK4c and p19IN...

Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a

Baumgartner, Roland
Fernandez-Catalan, Carlos
Winoto, Astar
Huber, Robert
Engh, Richard A
Holak, Tad A

October 1998

AbstractBackground: The four members of the INK4 gene family (p16INK4a, p15INK4b, p18INK4c and p19IN...

Dissection of Protein-Protein Interaction and CDK4 Inhibition in the Oncogenic versus Tumor Suppressing Functions of Gankyrin and P16

Mahajan, A

[[sponsorship]]基因體研究中心,生物化學研究所[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/g...

Structure-function studies and in silico drug discovery targeting the liver Oncoprotein Gankyrin.

Murchland, Iain

January 2013

Gankyrin is an ankyrin repeat protein known for its oncogenic effects and its up-regulation in the e...

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.

Chattopadhyay, Anasuya
O'Connor, Cornelius J
Zhang, Fengzhi
Galvagnion, Celine
Galloway, Warren
Tan, Yaw Sing
Stokes, Jamie E
Rahman, Md Taufiq
Verma, Chandra
Spring, David
Itzhaki, Laura

April 2016

Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the developmen...

Gankyrin Promotes Tumor-Suppressor Protein Degradation to Drive Hepatocyte ProliferationSummary

Amber M. D’Souza
Yanjun Jiang
Ashley Cast
Leila Valanejad
Mary Wright
Kyle Lewis
Meenasri Kumbaji
Sheeniza Shah
David Smithrud
Rebekah Karns
Soona Shin
Nikolai Timchenko

January 2018

Background & Aims: Uncontrolled liver proliferation is a key characteristic of liver cancer; however...

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4

Byeon, IJ

[[sponsorship]]基因體研究中心,生物化學研究所[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/g...

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4

Byeon, I. J.

[[sponsorship]]基因體研究中心,生物化學研究所[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/g...

Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell

Chattopadhyay, Anasuya
O’Connor, Cornelius J.
Zhang, Fengzhi
Galvagnion, Celine
Galloway, Warren R. J. D.
Tan, Yaw Sing
Stokes, Jamie E.
Rahman, Taufiq
Verma, Chandra
Spring, David R.
Itzhaki, Laura S.

January 2016

Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the developmen...

The crystal structure of Gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53

Krzywda, S.
Brzozowski, A.M.
Higashitsuji, H.
Fujita, J.
Welchman, R.
Dawson, S.
Mayer, R.J.
Wilkinson, A.J.

October 2003

Gankyrin is a 25-kDa hepatocellular carcinoma-associated protein that mediates protein-protein inter...

Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome*

Dawson, Simon
Apcher, Sebastien
Mee, Maureen
Higashitsuji, Hiroaki
Baker, Rohan
Uhle, Stefan
Dubiel, Wolfgang
Fujita, Jun
Mayer, R. John

December 2015

A yeast two-hybrid screen with the human S6 (TBP7, RPT3) ATPase of the 26 S proteasome has identifie...

Solution Structure of the Human Oncogenic Protein Gankyrin Containing Seven Ankyrin Repeats and Analysis of Its Structure-Function Relationship†,‡

January 2004

ABSTRACT: Human gankyrin (226 residues, 24.4 kDa) is a liver oncoprotein that plays an important rol...

Construction & Cloning of Wild Type & Mutant (ΔN307- ΔN313) Alleles of p16ink4a

Qurat-Ul-Ain (Scholar)
Khurshid.I.Andrabi (Guide)

January 2012

p16INK4a, a CDK4/CDK6 binding protein is an established tumour suppressor implicated in cell cycle r...

P16Ink4a tumor suppressor function in lung cancer cells involves cyclin-dependent kinase 2 inhibition by Cip/Kip protein redistribution. Cell Growth Differ. 11:507–515

Bryn Grimison
Thomas A. Langan
Robert A. Sclafani

January 2000

As cell cycle regulators whose activity is frequently altered in human cancers, cyclin-dependent kin...

Tumor suppressor p16INK4A: structural characterization of wild-type and mutant proteins by NMR and circular dichroism

Tevelev, A

[[sponsorship]]基因體研究中心,生物化學研究所[[note]]已出版;[SCI];有審查制度;不具代表性[[note]]http://gateway.isiknowledge.com/g...

Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a

Baumgartner, Roland
Fernandez-Catalan, Carlos
Winoto, Astar
Huber, Robert
Engh, Richard A
Holak, Tad A

October 1998

AbstractBackground: The four members of the INK4 gene family (p16INK4a, p15INK4b, p18INK4c and p19IN...

Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a

Baumgartner, Roland
Fernandez-Catalan, Carlos
Winoto, Astar
Huber, Robert
Engh, Richard A
Holak, Tad A

October 1998

AbstractBackground: The four members of the INK4 gene family (p16INK4a, p15INK4b, p18INK4c and p19IN...

Dissection of Protein-Protein Interaction and CDK4 Inhibition in the Oncogenic versus Tumor Suppressing Functions of Gankyrin and P16

Abstract

Extracted data

Dissection of Protein-Protein Interaction and CDK4 Inhibition in the Oncogenic versus Tumor Suppressing Functions of Gankyrin and P16

Abstract

Extracted data

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