Introduction: optimal treatment of Gram-negative infections in critically ill patients is challenged by changing pathophysiological conditions, reduced antimicrobial susceptibility and limited therapeutic options. The aim of this study was to assess the impact of maximizing Css/MIC ratio on efficacy of continuous infusion (CI) meropenem in treating documented Gram-negative infections in critically ill patients and to perform a population pharmacokinetic/pharmacodynamic analysis to support treatment optimization. Materials and Methods: Classification and regression tree (CART) analysis was used to identify whether a cutoff of steady-state meropenem concentration (Css)-to-minimum inhibitory concentration (MIC) (Css/MIC) ratio correlated with ...
Objectives: We utilized the database of the Defining Antibiotic Levels in Intensive care unit patien...
Objectives: We utilized the database of the Defining Antibiotic Levels in Intensive care unit patien...
Background: Emerging data suggest that more aggressive beta-lactam PK/PD targets could minimize the ...
Introduction: optimal treatment of Gram-negative infections in critically ill patients is challenged...
Background: The proper dosage of antibiotics is a key element in the effective treatment of infectio...
The worrisome increase in Gram-negative bacteria with borderline susceptibility to carbapenems and o...
International audienceBackground and Objectives: Meropenem is frequently used for the treatment of s...
Meropenem plasma concentration above a pathogen's MIC over the whole dosing interval (100% ƒT>MIC...
Objectives: The objective of this study was to explore the relationship between pharmacokinetic/phar...
Objective: Meropenem is a β-lactam, carbapenem antibacterial agent with antimicrobial activity again...
Background: Pathophysiological changes such as extreme body weights in critically ill patients with ...
Background: Pathophysiological changes such as extreme body weights in critically ill patients with ...
Background: Severe bacterial infections remain a major challenge in intensive care units because of ...
BACKGROUND AND OBJECTIVE: Meropenem is a carbapenem antibacterial frequently prescribed for the t...
Optimal antibiotic exposure is a vital but challenging prerequisite for achieving clinical success i...
Objectives: We utilized the database of the Defining Antibiotic Levels in Intensive care unit patien...
Objectives: We utilized the database of the Defining Antibiotic Levels in Intensive care unit patien...
Background: Emerging data suggest that more aggressive beta-lactam PK/PD targets could minimize the ...
Introduction: optimal treatment of Gram-negative infections in critically ill patients is challenged...
Background: The proper dosage of antibiotics is a key element in the effective treatment of infectio...
The worrisome increase in Gram-negative bacteria with borderline susceptibility to carbapenems and o...
International audienceBackground and Objectives: Meropenem is frequently used for the treatment of s...
Meropenem plasma concentration above a pathogen's MIC over the whole dosing interval (100% ƒT>MIC...
Objectives: The objective of this study was to explore the relationship between pharmacokinetic/phar...
Objective: Meropenem is a β-lactam, carbapenem antibacterial agent with antimicrobial activity again...
Background: Pathophysiological changes such as extreme body weights in critically ill patients with ...
Background: Pathophysiological changes such as extreme body weights in critically ill patients with ...
Background: Severe bacterial infections remain a major challenge in intensive care units because of ...
BACKGROUND AND OBJECTIVE: Meropenem is a carbapenem antibacterial frequently prescribed for the t...
Optimal antibiotic exposure is a vital but challenging prerequisite for achieving clinical success i...
Objectives: We utilized the database of the Defining Antibiotic Levels in Intensive care unit patien...
Objectives: We utilized the database of the Defining Antibiotic Levels in Intensive care unit patien...
Background: Emerging data suggest that more aggressive beta-lactam PK/PD targets could minimize the ...